Should i accept this blockbuster fantasy baseball trade?

I'd go for it. Sure you're giving up your ace, but you'll be getting a top 5 fantasy player back in Wright. Beltran and Berkman are probably going to give you around the same stats. Then your offense should be pretty sound, and you could even trade away some offense for another quality pitcher and still be okay. You also have to remember Peavy plays for the Padres, who probably aren't going to be all that great this year. Then of course you have to pray that your players stay healthy and the other guy's don't. ;)